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The effect of methotrexate upon tumour ATP as determined by in vivo 31 P inversion spin transfer
Author(s) -
Haseler Luke J.,
Irving Michael G.,
Doddrell David M.
Publication year - 1988
Publication title -
nmr in biomedicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.278
H-Index - 114
eISSN - 1099-1492
pISSN - 0952-3480
DOI - 10.1002/nbm.1940010305
Subject(s) - methotrexate , in vivo , nuclear magnetic resonance , chemistry , skeletal muscle , medicine , endocrinology , biophysics , biology , physics , microbiology and biotechnology
The effect of methotrexate upon tumour growth in the hind leg muscle of rats containing a transplanted mammary adenocarcinoma was investigated by 31 P magnetic resonance spectroscopy. Using inversion‐transfer techniques, ATP resonances arising from the tumour could be distinguished from those arising from surrounding skeletal muscle. Methotrexate was shown to inhibit, but not prevent, tumour growth as evidenced by the tumour ATP resonances of methotrexate treated animals compared to those of control animals. These findings correlated with decreased tumour volume and enhanced life expectancy.