Premium
The use of immobilized ferrite to enhance the depth selectivity of in vivo surface coil NMR spectroscopy
Author(s) -
Geoffrion Y.,
Rydzy M.,
Butler K. W.,
Smith Ian C. P.,
Jarrell Harold C.
Publication year - 1988
Publication title -
nmr in biomedicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.278
H-Index - 114
eISSN - 1099-1492
pISSN - 0952-3480
DOI - 10.1002/nbm.1940010302
Subject(s) - materials science , nuclear magnetic resonance spectroscopy , ferrite (magnet) , electromagnetic coil , nuclear magnetic resonance , in vivo , spectroscopy , resolution (logic) , selectivity , homogeneous , analytical chemistry (journal) , chemistry , computer science , chromatography , composite material , physics , biochemistry , microbiology and biotechnology , thermodynamics , quantum mechanics , artificial intelligence , biology , catalysis
Ferrite particles immobilized on a flexible support and arranged in a specific pattern will produce localized gradients in the homogeneous B 0 magnetic field. The screening gradients are strong enough to cause inhomogeneous broadening of the NMR signals arising from the region of a specimen which is adjacent to the ferrite particles. This technique allows improvement of the depth selectivity in non‐invasive surface coil NMR spectroscopy while optimizing both the signal‐to‐noise ratio and the data acquisition time of in vivo NMR experiments. The ferrite screen method also facilitates the routine application of high resolution NMR pulse sequences to in vivo experiments. The technique is readily implemented without special hardware or software and displays a great versatility in the size, shape and depth of the screening effect.