A simple and low‐cost device for generating hyperpolarized contrast agents using parahydrogen | Zendy

Kadlecek Stephen | Zendy; Vahdat Vahid | Zendy; Nakayama Takeshi | Zendy; Ng Danny | Zendy; Emami Kiarash | Zendy; Rizi Rahim | Zendy

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A simple and low‐cost device for generating hyperpolarized contrast agents using parahydrogen

Author(s) -

Kadlecek Stephen,

Vahdat Vahid,

Nakayama Takeshi,

Ng Danny,

Emami Kiarash,

Rizi Rahim

Publication year - 2011

Publication title -

nmr in biomedicine

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.278

H-Index - 114

eISSN - 1099-1492

pISSN - 0952-3480

DOI - 10.1002/nbm.1757

Subject(s) - spin isomers of hydrogen , hyperpolarization (physics) , heteronuclear molecule , chemistry , metastability , solvent , molecule , nuclear magnetic resonance , hydrogen , nuclear magnetic resonance spectroscopy , physics , stereochemistry , organic chemistry

A detailed description of the construction and use of a device for hyperpolarization of select contrast agents is presented. The device is based on molecular incorporation of the spin‐order inherent to parahydrogen, followed by order transfer to a metastable heteronuclear alignment. Design considerations and experimental results relating to catalyst/solvent choice and handling, solvent heating, efficient gas entrainment and spin‐order transfer are described. The resulting degree of hyperpolarization is shown to be substantial, ranging from a few to over 50%, depending on the choice of target molecule. Finally, the use of the hyperpolarized agent is demonstrated in a series of in vivo images. Copyright © 2011 John Wiley & Sons, Ltd.

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