Premium
A simple and low‐cost device for generating hyperpolarized contrast agents using parahydrogen
Author(s) -
Kadlecek Stephen,
Vahdat Vahid,
Nakayama Takeshi,
Ng Danny,
Emami Kiarash,
Rizi Rahim
Publication year - 2011
Publication title -
nmr in biomedicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.278
H-Index - 114
eISSN - 1099-1492
pISSN - 0952-3480
DOI - 10.1002/nbm.1757
Subject(s) - spin isomers of hydrogen , hyperpolarization (physics) , heteronuclear molecule , chemistry , metastability , solvent , molecule , nuclear magnetic resonance , hydrogen , nuclear magnetic resonance spectroscopy , physics , stereochemistry , organic chemistry
A detailed description of the construction and use of a device for hyperpolarization of select contrast agents is presented. The device is based on molecular incorporation of the spin‐order inherent to parahydrogen, followed by order transfer to a metastable heteronuclear alignment. Design considerations and experimental results relating to catalyst/solvent choice and handling, solvent heating, efficient gas entrainment and spin‐order transfer are described. The resulting degree of hyperpolarization is shown to be substantial, ranging from a few to over 50%, depending on the choice of target molecule. Finally, the use of the hyperpolarized agent is demonstrated in a series of in vivo images. Copyright © 2011 John Wiley & Sons, Ltd.