Premium
Localized 1 H NMR spectroscopy in different regions of human brain in vivo at 7 T: T 2 relaxation times and concentrations of cerebral metabolites
Author(s) -
Marjańska Małgorzata,
Auerbach Edward J.,
Valabrègue Romain,
Van de Moortele PierreFrançois,
Adriany Gregor,
Garwood Michael
Publication year - 2012
Publication title -
nmr in biomedicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.278
H-Index - 114
eISSN - 1099-1492
pISSN - 0952-3480
DOI - 10.1002/nbm.1754
Subject(s) - occipital lobe , human brain , nuclear magnetic resonance , neurochemical , cortex (anatomy) , relaxation (psychology) , in vivo , cerebellum , chemistry , cerebral cortex , t2 relaxation , metabolite , neuroscience , physics , biology , medicine , magnetic resonance imaging , biochemistry , microbiology and biotechnology , radiology
At the high field strength of 7 T, in vivo spectra of the human brain with exceptional spectral quality sufficient to quantify 16 metabolites have been obtained previously only in the occipital lobe. However, neurochemical abnormalities associated with many brain disorders are expected to occur in brain structures other than the occipital lobe. The purpose of the present study was to obtain high‐quality spectra from various brain regions at 7 T and to quantify the concentrations of different metabolites. To obtain concentrations of metabolites within four different regions of the brain, such as the occipital lobe, motor cortex, basal ganglia and cerebellum, the T 2 relaxation times of the singlets and J ‐coupled metabolites in these regions were measured for the first time at 7 T. Our results demonstrate that high‐quality, quantifiable spectra can be obtained in regions other than the occipital lobe at 7 T utilizing a 16‐channel transceiver coil and B 1 + shimming. Copyright © 2011 John Wiley & Sons, Ltd.