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MRS characterization of central neurocytomas using glycine
Author(s) -
Shah Tariq,
Jayasundar Rama,
Singh Virendera Paul,
Sarkar Chitra
Publication year - 2011
Publication title -
nmr in biomedicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.278
H-Index - 114
eISSN - 1099-1492
pISSN - 0952-3480
DOI - 10.1002/nbm.1705
Subject(s) - central neurocytoma , glycine , in vivo , alanine , in vivo magnetic resonance spectroscopy , choline , high resolution , chemistry , nuclear magnetic resonance , nuclear medicine , pathology , biology , medicine , radiology , magnetic resonance imaging , biochemistry , amino acid , genetics , physics , geology , remote sensing
This study reports in vivo MRS findings in 11 patients with histologically diagnosed central neurocytomas, which are rare intraventricular tumors of neuronal origin. Single‐voxel 1 H MRS was carried out prior to surgery using a point‐resolved spectroscopy sequence with TR = 6 s, TE = 135 ms and 128 scans. In vitro high‐resolution 1 H spectroscopy was also carried out on two surgically excised samples. The striking features of the spectra from the central neurocytomas were the presence of high glycine, decreased N ‐acetylaspartate, increased choline and alanine. Retrospective, blind analysis of the spectra by two independent observers correctly identified all but one central neurocytoma based on the presence of glycine. The presence of glycine and prominent choline in the 1 H MR spectrum is a characteristic feature of the central neurocytomas, and could be used to characterize and differentiate them from other brain tumors. Copyright © 2011 John Wiley & Sons, Ltd.