Premium
7‐T 1 H MRS with adiabatic refocusing at short TE using radiofrequency focusing with a dual‐channel volume transmit coil
Author(s) -
Boer V.O.,
van Lier A.L.H.M.W.,
Hoogduin J.M.,
Wijnen J.P.,
Luijten P.R.,
Klomp D.W.J.
Publication year - 2011
Publication title -
nmr in biomedicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.278
H-Index - 114
eISSN - 1099-1492
pISSN - 0952-3480
DOI - 10.1002/nbm.1641
Subject(s) - adiabatic process , amplifier , bandwidth (computing) , electromagnetic coil , nuclear magnetic resonance , physics , displacement (psychology) , radiofrequency coil , signal (programming language) , optics , atomic physics , computational physics , chemistry , computer science , telecommunications , psychology , quantum mechanics , psychotherapist , thermodynamics , programming language
In vivo MRS of the human brain at ultrahigh field allows for the identification of a large number of metabolites at higher spatial resolutions than currently possible in clinical practice. However, the in vivo localization of single‐voxel spectroscopy has been shown to be challenging at ultrahigh field because of the low bandwidth of refocusing radiofrequency (RF) pulses. Thus far, the proposed methods for localized MRS at 7 T suffer from long TE, inherent signal loss and/or a large chemical shift displacement artifact that causes a spatial displacement between resonances, and results in a decreased efficiency in editing sequences. In this work, we show that, by driving a standard volume coil with two RF amplifiers, focusing the B 1 +field in a certain location and using high‐bandwidth adiabatic refocusing pulses, a semi‐LASER (semi‐localized by adiabatic selective refocusing) localization is feasible at short TE in the human brain with full signal acquisition and a low chemical shift displacement artifact at 7 T. Copyright © 2011 John Wiley & Sons, Ltd.