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Lipid profiling of cancerous and benign gallbladder tissues by 1 H NMR spectroscopy
Author(s) -
Jayalakshmi Kamaiah,
Sonkar Kanchan,
Behari Anu,
Kapoor Vinay K.,
Sinha Neeraj
Publication year - 2011
Publication title -
nmr in biomedicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.278
H-Index - 114
eISSN - 1099-1492
pISSN - 0952-3480
DOI - 10.1002/nbm.1594
Subject(s) - gallbladder , cholecystitis , chemistry , gallbladder cancer , pathology , nuclear magnetic resonance spectroscopy , gallbladder disease , chronic cholecystitis , medicine , stereochemistry
Qualitative and quantitative 1 H NMR analysis of lipid extracts of gallbladder tissue in chronic cholecystitis (CC, benign) ( n = 14), xanthogranulomatous cholecystitis (XGC, intermediate) ( n = 9) and gallbladder cancer (GBC, malignant) ( n = 8) was carried out to understand the mechanisms involved in the transformation of benign gallbladder tissue to intermediate and malignant tissue. The results revealed alterations in various tissue lipid components in gallbladder in CC, XGC and GBC. The difference in the nature of lipid components in benign and malignant disease may aid in the identification of the biological pathways involved in the etiopathogenesis of GBC. This is the first study on lipid profiling of gallbladder tissue by 1 H NMR spectroscopy, and has possible implications for the development of future diagnostic approaches. Copyright © 2010 John Wiley & Sons, Ltd.