Premium
13 C MRS of occipital and frontal lobes at 3 T using a volume coil for stochastic proton decoupling
Author(s) -
Li Shizhe,
Zhang Yan,
Wang Shumin,
Araneta Maria Ferraris,
Johnson Christopher S.,
Xiang Yun,
Innis Robert B.,
Shen Jun
Publication year - 2010
Publication title -
nmr in biomedicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.278
H-Index - 114
eISSN - 1099-1492
pISSN - 0952-3480
DOI - 10.1002/nbm.1524
Subject(s) - decoupling (probability) , nuclear magnetic resonance , electromagnetic coil , frontal lobe , chemistry , physics , spectral line , proton , in vivo , occipital lobe , nuclear medicine , neuroscience , medicine , nuclear physics , biology , microbiology and biotechnology , quantum mechanics , control engineering , astronomy , engineering
Previously, we devised a novel strategy for in vivo 13 C MRS using [2‐ 13 C]glucose infusion and low‐power proton decoupling, and proposed that this strategy could be used to acquire 13 C MR spectra from the frontal lobe of the human brain. Here, we demonstrate, for the first time, in vivo 13 C MRS of human frontal lobe acquired at 3 T. Because the primary metabolites of [2‐ 13 C]glucose can be decoupled using very‐low‐radiofrequency power, we used a volume coil for proton decoupling in this study. The homogeneous B 1 field of the volume coil was found to significantly enhance the decoupling efficiency of the stochastic decoupling sequence. Detailed specific absorption rates inside the human head were analyzed using the finite difference time domain method to ensure experimental safety. In vivo 13 C spectra from the occipital and frontal lobes of the human brain were obtained. At a decoupling power of 30 W (time‐averaged power, 2.45 W), the spectra from the occipital lobe showed well‐resolved spectral resolution and excellent signal‐to‐noise ratio. Although frontal lobe 13 C spectra were affected by local B 0 field inhomogeneity, we demonstrated that the spectral quality could be improved using post‐acquisition data processing. In particular, we showed that the frontal lobe glutamine C5 at 178.5 ppm and aspartate C4 at 178.3 ppm could be spectrally resolved with effective proton decoupling and B 0 field correction. Because of its large spatial coverage, volume coil decoupling provides the potential to acquire 13 C MRS from more than one brain region simultaneously. Copyright © 2010 John Wiley & Sons, Ltd.