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Comparison of hyperpolarized 3 He MRI rat lung volume measurement with micro‐computed tomography
Author(s) -
Sharif M. Reza Akhavan,
Lam Wilfred W.,
Ouriadov Alexei V.,
Holdsworth David W.,
Santyr Giles E.
Publication year - 2010
Publication title -
nmr in biomedicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.278
H-Index - 114
eISSN - 1099-1492
pISSN - 0952-3480
DOI - 10.1002/nbm.1470
Subject(s) - computed tomography , nuclear magnetic resonance , nuclear medicine , magnetic resonance imaging , volume (thermodynamics) , chemistry , physics , materials science , medicine , radiology , quantum mechanics
In this study, the upper‐limit volume (gas plus partial tissue volume) as well as absolute volume (gas only) of lungs measured with hyperpolarized 3 He‐MR imaging is compared with that determined by micro‐computed tomography (CT) under similar ventilation conditions in normal rats. Five Brown Norway rats (210–259 g) were ventilated with O 2 , alternately with 3 He, using a computer‐controlled ventilator, and 3D density‐weighted images of the lungs were acquired during a breath hold after six wash‐in breaths of 3 He. The rats were then transferred to a micro‐CT scanner, and a similar experimental setup was used to obtain images of the lungs during a breath hold of air with an airway pressure equal to that of the MR imaging breath hold. The upper‐limit and absolute volumes obtained from 3 He‐MR and micro‐CT methods were not significantly different ( p > 0.05). The good agreement between the lung volumes measured with the two imaging methods suggests that 3 He‐MR imaging can be used for quantitative analysis of lung volume changes in longitudinal studies without the exposure to the ionizing radiation which accompanies micro‐CT imaging. Copyright © 2010 John Wiley & Sons, Ltd.