Premium
Which pulse sequence is optimal for myo‐inositol detection at 3T?
Author(s) -
Hancu Ileana
Publication year - 2009
Publication title -
nmr in biomedicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.278
H-Index - 114
eISSN - 1099-1492
pISSN - 0952-3480
DOI - 10.1002/nbm.1353
Subject(s) - pulse sequence , sequence (biology) , pulse (music) , filter (signal processing) , repeatability , nuclear magnetic resonance , physics , chemistry , optics , computer science , chromatography , biochemistry , detector , computer vision
Abstract Optimized myo‐inositol (mI) detection is important for diagnosing and monitoring a multitude of pathological conditions of the brain. Simulations are presented in this work, performed to decide which pulse sequence has the most significant advantage in terms of improving repeatability and accuracy of mI measurements at 3T over the pulse sequence used typically in the clinic, a TE = 35 ms PRESS sequence. Five classes of pulse sequences, four previously suggested for optimized mI detection (a short TE PRESS, a Carr‐Purcell PRESS sequence, an optimized STEAM sequence, an optimized zero quantum filter), and one optimized for mI detection in this work (a single quantum filter) were compared to a standard, TE = 35 ms pulse sequence. While limiting the SNR of an acquisition to the equivalent SNR of a spectrum acquired in 5 min from an 8 cc voxel, it was found through simulations that the most repeatable mI measurements would be obtained with a Carr‐Purcell sequence. This sequence was implemented in a clinical scanner, and improved mI measurements were demonstrated in vivo . Copyright © 2008 John Wiley & Sons, Ltd.