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MRI in experimental inflammatory and mitochondrial optic neuropathies
Author(s) -
Guy John
Publication year - 2008
Publication title -
nmr in biomedicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.278
H-Index - 114
eISSN - 1099-1492
pISSN - 0952-3480
DOI - 10.1002/nbm.1309
Subject(s) - optic nerve , neurodegeneration , pathology , pathogenesis , experimental autoimmune encephalomyelitis , neuroscience , medicine , disease , magnetic resonance imaging , encephalomyelitis , biology , central nervous system , radiology
MRI is a powerful tool for evaluating structural and functional alterations in the optic nerve in experimental animal models of human disease. MRI–histopathological correlations have provided important insights into the pathogenesis of disease. Paramagnetic contrast agents have been used to serially visualize the foci and severity of disruption of the blood–optic nerve barrier and physiological neuronal alterations in living animals. Here I review the experience of our group in optic nerve imaging of experimental autoimmune encephalomyelitis and neurodegeneration induced by genetic manipulation of respiratory chain enzymes. Copyright © 2008 John Wiley & Sons, Ltd.