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Measurement of nonlinear p O 2 decay in mouse lungs using 3 He‐MRI
Author(s) -
Cieślar Katarzyna,
Alsaid Hasan,
Stupar Vasile,
Gaillard Sophie,
CanetSoulas Emmanuelle,
Fissoune Rachida,
Crémillieux Yannick
Publication year - 2007
Publication title -
nmr in biomedicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.278
H-Index - 114
eISSN - 1099-1492
pISSN - 0952-3480
DOI - 10.1002/nbm.1124
Subject(s) - oxygen , chemistry , analytical chemistry (journal) , exponential decay , time constant , partial pressure , constant (computer programming) , nuclear magnetic resonance , physics , chromatography , nuclear physics , organic chemistry , computer science , electrical engineering , programming language , engineering
Spatial and temporal variations in oxygen partial pressure ( p O 2 ) during breath‐hold can be exploited to obtain important regional parameters of lung function. In the course of apnea, the oxygen concentration is known to decay exponentially. Therefore, the initial p O 2 ( p 0 ) can be used to represent local ventilation, and the oxygen depletion time constant can characterize perfusion. The protocol, based on a nonlinear model of p O 2 decay, was validated in six healthy mice. Parametric maps of p 0 and oxygen depletion time constant were obtained for pure 3 He and 3 He/air mixture. The mean measured values of p 0 were 77 ± 9 mbar for the pure 3 He insufflation and 107 ± 5 mbar for 3 He/air mixture, in agreement with the predefined p 0 values: 75 ± 15 mbar and 123 ± 15 mbar, respectively. The mean measured oxygen depletion time constants were 6.5 ± 0.2 s for pure 3 He and 7.1 ± 0.8 s for the 3 He/air mixture, in agreement with physiology. Copyright © 2007 John Wiley & Sons, Ltd.
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