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Comparison between prospective and retrospective triggering for mouse cardiac MRI
Author(s) -
Heijman Edwin,
de Graaf Wolter,
Niessen Petra,
Nauerth Arno,
van Eys Guillaume,
de Graaf Larry,
Nicolay Klaas,
Strijkers Gustav J.
Publication year - 2007
Publication title -
nmr in biomedicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.278
H-Index - 114
eISSN - 1099-1492
pISSN - 0952-3480
DOI - 10.1002/nbm.1110
Subject(s) - ventricle , ejection fraction , magnetic resonance imaging , stroke volume , prospective cohort study , retrospective cohort study , medicine , cardiac magnetic resonance imaging , cardiac cycle , communication noise , cardiology , contrast to noise ratio , nuclear medicine , radiology , heart failure , image quality , artificial intelligence , computer science , linguistics , philosophy , image (mathematics)
Abstract High‐resolution magnetic resonance imaging (MRI) has evolved into one of the major non‐invasive tools to study the healthy and diseased mouse heart. This study presents a Cartesian CINE MRI protocol based on a fast low‐angle shot sequence with a navigator echo to generate cardiac triggering and respiratory gating signals retrospectively, making the use of ECG leads and respiratory motion sensors obsolete. MRI of the in vivo mouse heart using this sequence resulted in CINE images with no detectable cardiac and respiratory motion artefacts. The retrospective method allows for steady‐state imaging of the mouse heart, which is essential for quantitative contrast‐enhanced MRI studies. A comparison was made between prospective and retrospective methods in terms of the signal‐to‐noise ratio and the contrast‐to‐noise ratio between blood and myocardial wall, as well as global cardiac functional indices: end‐diastolic volume, end‐systolic volume, stroke volume and ejection fraction. The retrospective method resulted in almost constant left‐ventricle wall signal intensity throughout the cardiac cycle, at the expense of a decrease in the signal‐to‐noise ratio and the contrast‐to‐noise ratio between blood and myocardial wall as compared with the prospective method. Prospective and retrospective sequences yielded comparable global cardiac functional indices. The largest mean relative difference found was 8% for the end‐systolic volume. Copyright © 2006 John Wiley & Sons, Ltd.