Premium
Dynamic MRS and MRI of skeletal muscle function and biomechanics
Author(s) -
Prompers Jeanine J.,
Jeneson Jeroen A. L.,
Drost Maarten R.,
Oomens Cees C. W.,
Strijkers Gustav J.,
Nicolay Klaas
Publication year - 2006
Publication title -
nmr in biomedicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.278
H-Index - 114
eISSN - 1099-1492
pISSN - 0952-3480
DOI - 10.1002/nbm.1095
Subject(s) - skeletal muscle , muscle disease , myocyte , function (biology) , muscle contraction , in vivo , biomechanics , biomedical engineering , medicine , neuroscience , anatomy , biology , pathology , disease , microbiology and biotechnology
MR is a powerful technique for studying the biomechanical and functional properties of skeletal muscle in vivo in health and disease. This review focuses on 31 P, 1 H and 13 C MR spectroscopy for assessment of the dynamics of muscle metabolism and on dynamic 1 H MRI methods for non‐invasive measurement of the biomechanical and functional properties of skeletal muscle. The information thus obtained ranges from the microscopic level of the metabolism of the myocyte to the macroscopic level of the contractile function of muscle complexes. The MR technology presented plays a vital role in achieving a better understanding of many basic aspects of muscle function, including the regulation of mitochondrial activity and the intricate interplay between muscle fiber organization and contractile function. In addition, these tools are increasingly being employed to establish novel diagnostic procedures as well as to monitor the effects of therapeutic and lifestyle interventions for muscle disorders that have an increasing impact in modern society. Copyright © 2006 John Wiley & Sons, Ltd.