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Retrospective cine 3 He ventilation imaging under spontaneous breathing conditions: a non‐invasive protocol for small‐animal lung function imaging
Author(s) -
Stupar Vasile,
CanetSoulas Emmanuelle,
Gaillard Sophie,
Alsaid Hasan,
Beckmann Nicolau,
Crémillieux Yannick
Publication year - 2007
Publication title -
nmr in biomedicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.278
H-Index - 114
eISSN - 1099-1492
pISSN - 0952-3480
DOI - 10.1002/nbm.1086
Subject(s) - ventilation (architecture) , breathing , lung ventilation , nuclear medicine , reproducibility , image resolution , lung , biomedical engineering , medicine , chemistry , anatomy , physics , optics , chromatography , thermodynamics
A non‐invasive and free‐breathing hyperpolarized (HP) 3 He imaging protocol for small animals was implemented and validated on rats for lung function imaging. Animals were allowed to breathe a mixture of air and 3 He from a mask and a gas reservoir fitted to their heads. Radial imaging sequences were used, and MRI signal intensity changes were monitored for retrospective cine image reconstruction. The ventilation cycle of the animals was imaged with a 100 ms temporal resolution. The sliding window imaging technique was applied to reconstruct 5 ms time‐shifted image series covering the complete breathing cycle. Image series were processed to extract quantitative ventilation parameters such as the gas arrival time. The reproducibility and the non‐invasiveness of this ventilation imaging protocol were evaluated by multiple acquisitions on the same animals. Copyright © 2006 John Wiley & Sons, Ltd.