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Single‐voxel 1 H PRESS at 4.0 T: precision and variability of measurements in anterior cingulate and hippocampus
Author(s) -
Venkatraman Talaignair N.,
Hamer Robert M.,
Perkins Diana O.,
Song Allen W.,
Lieberman Jeffrey A.,
Steen R. Grant
Publication year - 2006
Publication title -
nmr in biomedicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.278
H-Index - 114
eISSN - 1099-1492
pISSN - 0952-3480
DOI - 10.1002/nbm.1055
Subject(s) - hippocampus , coefficient of variation , voxel , anterior cingulate cortex , nuclear medicine , nuclear magnetic resonance , diagnostic accuracy , medicine , neuroscience , chemistry , psychology , radiology , physics , chromatography , cognition
The precision [coefficient of variation or CV (%) = 100SD/ X ] of single‐voxel point resolved spectroscopic data was characterized bilaterally, in anterior cingulate and in hippocampus, at 4.0 T in a healthy subject. Data acquisition was replicated 10 times after voxel repositioning and readjusting higher order shims. Precision measurements show that the scan‐to‐scan precision is better in anterior cingulate than in hippocampus, with an average CV of 9.2% (for total NAA, tCho and Cr) in anterior cingulate and 13.9% in hippocampus. Variability measurements made by the same method in 24 healthy subjects and in 29 schizophrenia patients showed that there is substantial biological variability in metabolite levels, even in healthy subjects. Simple calculations suggest that more than 200 subjects would be needed to detect a 5% difference in NAA between patients and controls. Copyright © 2006 John Wiley & Sons, Ltd.