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Ultra‐short echo time spectroscopic imaging in rats: implications for monitoring lipids in glioma gene therapy
Author(s) -
Liimatainen Timo,
Hakumäki Juhana,
Tkáč Ivan,
Gröhn Olli
Publication year - 2006
Publication title -
nmr in biomedicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.278
H-Index - 114
eISSN - 1099-1492
pISSN - 0952-3480
DOI - 10.1002/nbm.1031
Subject(s) - glioma , magnetic resonance imaging , gene , nuclear magnetic resonance , herpes simplex virus , thymidine kinase , biology , chemistry , cancer research , virus , medicine , biochemistry , physics , virology , radiology
We demonstrate the feasibility of using ultra‐short echo time ( TE = 2 ms) magnetic resonance spectroscopic imaging (MRSI) to detect intracranial mobile lipids in the rat brain. High‐performance outer volume suppression and pre‐localization were demonstrated in phantoms and by the total absence of signals arising from extra‐cranial lipids in MRSI spectra from control rats. The sequence performance was tested on glioma‐bearing BDIX rats. Fast‐relaxing lipid signals were spatially varied within a glioma during herpes simplex virus thymidine kinase‐mediated gene therapy, demonstrating the potential application of this method. Copyright © 2006 John Wiley & Sons, Ltd.