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Association of nocturia and cardiovascular disease: Data from the National Health and Nutrition Examination Survey
Author(s) -
Moon Shinje,
Yu Sung Hoon,
Chung Hye Soo,
Kim Yoon Jung,
Yu Jae Myung,
Kim Sung Jin,
Kwon Ohseong,
Lee Young Goo,
Cho Sung Tae
Publication year - 2021
Publication title -
neurourology and urodynamics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.918
H-Index - 90
eISSN - 1520-6777
pISSN - 0733-2467
DOI - 10.1002/nau.24711
Subject(s) - nocturia , medicine , national health and nutrition examination survey , body mass index , odds ratio , logistic regression , confidence interval , diabetes mellitus , confounding , dyslipidemia , disease , environmental health , urinary system , endocrinology , population
Aims To investigate the association of nocturia with the prevalence of cardiovascular disease (CVD) using the National Health and Nutrition Examination Survey (NHANES) data. Methods Among the 40 790 individuals who participated in NHANES from 2005 to 2012, 14 114 adults were analyzed in this study. A participant was considered to have nocturia if they have two or more voiding episodes nightly. In addition, participants with nocturia more than four times in a day were considered to have severe nocturia. A multivariate logistic regression analysis with adjustment for confounding variables, including age, sex, race, body mass index (BMI), smoking status, alcohol consumption, sleeping time, dyslipidemia, hypertension, and diabetes mellitus was performed with 1:1 propensity score matching (PSM). Results Nocturia occurred in 4610 individuals (32.7%). The prevalence of CVD was significantly higher in men, older individuals, those with higher BMI, smokers, and those with diabetes, hypertension, and hyperlipidemia. There was also a significantly higher prevalence of nocturia in the participants with CVD. Multivariate analysis showed that odds ratios (ORs) of mild and severe nocturia for CVD were 1.23 (95% confidence interval [CI]: 1.08–1.39) and 1.74 (95% CI: 1.39–2.17), respectively. After 1:1 PSM, the ORs of mild and severe nocturia were 1.27 (95% CI: 1.10–1.48) and 1.73 (95% CI: 1.33–2.26), respectively, showing statistical significance. Conclusion Data from the NHANES indicate that CVD was significantly associated with the prevalence of nocturia, after taking major confounding factors into account. Furthermore, the risk for CVD increases with increasing nocturia severity.

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