Premium
Beneficial effect of Bletilla striata extract solution on zymosan‐induced interstitial cystitis in rat
Author(s) -
Liu YiChing,
Lee WeiTing,
Liang ChingChung,
Lo TsiaShu,
Hsieh WuChiao,
Lin YiHao
Publication year - 2021
Publication title -
neurourology and urodynamics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.918
H-Index - 90
eISSN - 1520-6777
pISSN - 0733-2467
DOI - 10.1002/nau.24630
Subject(s) - medicine , interstitial cystitis , zymosan , overactive bladder , urinary bladder , urination , urology , detrusor muscle , anesthesia , urinary system , pathology , biochemistry , chemistry , alternative medicine , in vitro
Aims Interstitial cystitis (IC) is a chronic pain syndrome that is characterized by suprapubic pain upon bladder filling. Bletilla striata , a well‐known traditional Chinese herb with established efficacy in wound healing and anti‐inflammation, was hypothesized to improve the symptoms of IC possibly though forming a physical barrier that could isolate the bladder tissue from irritants. This study was conducted to evaluate the beneficial effects of intravesical treatment with B. striata extract solution (BSES) on visceral pain and bladder function of rats with zymosan‐induced IC. Methods Thirty female rats were randomly divided into control group, zymosan‐induced cystitis rats treated with normal saline (Z + NS), and zymosan‐induced cystitis rats treated with BSES (Z + BSES). All rats underwent evaluation for abdominal withdrawal reflex (AWR) scores to assess visceral hypersensitivity, cystometrography, and electromyogram (EMG) of both external urethral sphincter and bladder detrusor. Data were analyzed by one way analysis of variance. Results The Z + NS group had an increased visceral hypersensitivity as compared to control group. Rats treated with BSES (Z + BSES group) had decreased AWR scores and amplitude of bladder detrusor‐EMG. Besides, BSES treatment improved overactive bladder with significant effects on the extend of micturition interval and increase of storage of urine. Conclusions Intravesical instillation of BSES can significantly alleviate zymosan‐induced visceral hypersensitivity and bladder overactivity associated with IC. This study suggested that intravesical instillation with BSES might be a promising treatment for IC.