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Impairment of accessory nerves around major pelvic ganglion leading to overflow urinary incontinence in rats
Author(s) -
Maeda Kotomi,
Hotta Yuji,
Shibayama Maaya,
Kawata Ryoya,
Kataoka Tomoya,
Matsumoto Seiji,
Yamamoto Tokunori,
Kimura Kazunori
Publication year - 2021
Publication title -
neurourology and urodynamics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.918
H-Index - 90
eISSN - 1520-6777
pISSN - 0733-2467
DOI - 10.1002/nau.24612
Subject(s) - medicine , cystometry , urology , urinary system , fibrosis , urinary bladder , urinary incontinence , ganglion , urethra , anatomy
Aims To investigate the relationship between lower urinary tract function and the accessory nerve (ACN) arising from the major pelvic ganglion (MPG). Methods Ten‐week‐old male Wistar/ST rats were randomly divided into eight groups according to the type of treatment (sham or bilateral accessory nerve injury [BACNI]) and the duration of observation (3 days, 1 week, 2 weeks, or 4 weeks: Sham‐3d, Sham‐1w, Sham‐2w, Sham‐4w, BACNI‐3d, BACNI‐1w, BACNI‐2ws, and BACNI‐4w. BACNI was induced in the following manner: the ACN was crushed for 1 min (2 mm away from the MPG) using reverse‐action tweezers. The same procedure was performed on both sides. On the last day of each observation period, the bladder function was measured by awake cystometry, and histological evaluation was performed. Results All rats in the Sham groups micturated normally. In the BACNI‐3d and BACNI‐1w groups, all rats showed symptoms of overflow urinary incontinence (OUI). This OUI improved gradually over time. The bladder's size in the BACNI group was significantly larger than that in the Sham group ( p < .01). In addition, fibrosis was observed in the subserosa of the bladder of rats in BACNI groups. Conclusion The BACNI model rats exhibited OUI, suggesting that ACN is involved in the lower urinary tract function. It might be possible that ACN controls the function of either the bladder, the urethra, or both.