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Efficacy of transcutaneous posterior tibial nerve stimulation in children with functional voiding disorders
Author(s) -
Jafarov Ruslan,
Ceyhan Erman,
Kahraman Oguzhan,
Ceylan Taner,
Dikmen Zeliha G.,
Tekgul Serdar,
Dogan Hasan S.
Publication year - 2021
Publication title -
neurourology and urodynamics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.918
H-Index - 90
eISSN - 1520-6777
pISSN - 0733-2467
DOI - 10.1002/nau.24575
Subject(s) - medicine , randomization , quality of life (healthcare) , tibial nerve , urinary incontinence , randomized controlled trial , analysis of variance , urinary system , stimulation , urology , anesthesia , physical therapy , nursing
Aims To assess the efficacy of transcutaneous posterior tibial nerve stimulation (TPTNS) on functional voiding disorder (FVD) and investigate the utility of urine biomarkers (UBs: nerve growth factor, transforming growth factor‐beta 1, and tissue inhibitor of metalloproteinases 2) in diagnosis and follow‐up. Methods A total of 44 children were included to this randomized controlled trial prospectively. After randomization, 20 of 30 children with storage phase dysfunction those were unresponsive or noncompliant to medical treatment received TPTNS treatment (test group) and 10 children underwent TPTNS with no current (sham group) for 12 weeks. Fourteen healthy children constituted the nonsymptomatic group. UB levels, dysfunctional voiding and incontinence scoring system (DVISS), voiding diary, and quality of life (QoL) scores were assessed before and after treatment in the treatment groups. Results QoL scores, overall and day‐time DVISS scores were significantly decreased in both sham and test groups ( p < 0.05). In addition to these findings, the frequency of incontinence and urgency episodes were also significantly reduced ( p < 0.05) in the TPTNS treatment group. This effect in the test group was still valid 2 years after intervention. There was no significant difference in UBs measurements between treatment and nonsymptomatic groups and between pretreatment and posttreatment measurements of test and sham groups. Conclusions TPTNS is an efficient minimally invasive treatment in children with FVD who do not respond to medical treatment. TPTNS provides a significant improvement on episodes of frequency, episodes of incontinence, overall and day‐time DVISS scores, and QoL scores. The effectiveness of treatment continues even at the end of the second year of intervention. UBs were not found to be predictive in terms of diagnosis and evaluating the treatment response.