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Urinary nerve growth factor can predict therapeutic efficacy in children with monosymptomatic nocturnal enuresis
Author(s) -
Morizawa Yosuke,
Aoki Katsuya,
Iemura Yusuke,
Hori Shunta,
Gotoh Daisuke,
Fukui Shinji,
Nakai Yasushi,
Miyake Makito,
Torimoto Kazumasa,
Tanaka Nobumichi,
Fujimoto Kiyohide
Publication year - 2019
Publication title -
neurourology and urodynamics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.918
H-Index - 90
eISSN - 1520-6777
pISSN - 0733-2467
DOI - 10.1002/nau.24142
Subject(s) - medicine , creatinine , nerve growth factor , urinary system , enuresis , urology , desmopressin , brain derived neurotrophic factor , neurotrophic factors , endocrinology , receptor
Aim To determine the urinary levels of nerve growth factor (NGF) and brain‐derived neurotrophic factor (BDNF) in children with monosymptomatic nocturnal enuresis (MNE) and evaluate whether these factors can be used as biomarkers for the treatment outcome. Methods NGF and BDNF levels were measured and compared in 38 children (28 boys and 10 girls) with MNE and 25 children (18 boys and 7 girls) with no urinary symptoms were assessed. The mean ages in the patient and control groups were 9 and 10 years, respectively ( P = .49). The patients were treated with either alarm or desmopressin therapy. Results The urinary NGF/creatinine and BDNF/creatinine ratios were significantly higher in the patient group than in the control group ( P = .0003 and P = .0095, respectively). NGF and BDNF levels showed a significant positive correlation ( P = .0020, r = 0.40). With respect to the degree of response, 19 patients (50%) showed complete response (CR) or partial response (PR), and 19 patients (50%) showed nonresponse (NR). The urinary NGF/creatinine and BDNF/creatinine ratios were significantly higher in the NR group than in the CR and PR groups ( P = .0003 and P = .0003, respectively). Conclusions Urinary NGF/creatinine and BDNF/creatinine ratios were significantly higher in children with MNE than in healthy controls. Urinary NGF/creatinine can be predictive factors of a poor treatment outcome in children with MNE.