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One‐year results with selective bladder denervation in women with refractory overactive bladder
Author(s) -
Rovner Eric S.,
Versi Eboo,
Le Mai Tu,
Dmochowski Roger R.,
Wachter Stefan
Publication year - 2019
Publication title -
neurourology and urodynamics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.918
H-Index - 90
eISSN - 1520-6777
pISSN - 0733-2467
DOI - 10.1002/nau.24110
Subject(s) - overactive bladder , medicine , trigone of urinary bladder , urology , quality of life (healthcare) , refractory (planetary science) , urinary incontinence , adverse effect , prospective cohort study , urinary system , urinary bladder , surgery , nursing , physics , alternative medicine , pathology , astrobiology
Aims : To report 1‐year results with selective bladder denervation (SBD) of the trigone in women with refractory overactive bladder (OAB). Methods : In this prospective, international, multicenter case series, women with refractory OAB underwent a single SBD treatment of the bladder subtrigone region using temperature‐controlled radiofrequency. Patients were followed for 1 year and evaluated for changes in OAB symptoms and adverse events. Results : Among 35 women, 29 (83%) returned for 1‐year follow up. Median symptom reductions based on 3‐day bladder diaries were 68% for urgency urinary incontinence ( P < .001), 67% for urinary incontinence ( P < .001), 43% for urgency episodes ( P < .001), 5% for urinary frequency ( P = .19), and 33% for the total urgency and frequency score ( P < .001), with the majority of treatment benefit realized in the first month. Treatment benefit was reported in 72% of patients, the clinical success rate (≥50% reduction in urgency urinary incontinence) was 69%, and the dry rate was 10%. Statistically significant improvements occurred on Symptom Bother and Health‐related Quality of Life scales on the Overactive Bladder questionnaire, and on 6 of 9 King's Health Questionnaire domains. Patients with less severe baseline symptoms had similar quality of life improvements as those with more severe baseline symptoms. Device‐ or procedure‐related adverse events were reported in 6 (17%) patients. Conclusions : A single treatment with selective bladder denervation is durable for 1‐year in a significant proportion of women with refractory overactive bladder.