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A new outcome measure for LUTS: Symptoms of Lower Urinary Tract Dysfunction Research Network Symptom Index‐29 (LURN SI‐29) questionnaire
Author(s) -
Cella David,
Smith Abigail R.,
Griffith James W.,
Flynn Kathryn E.,
Bradley Catherine S.,
Gillespie Brenda W.,
Kirkali Ziya,
Talaty Pooja,
Jelovsek J. Eric,
Helfand Brian T.,
Weinfurt Kevin P.
Publication year - 2019
Publication title -
neurourology and urodynamics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.918
H-Index - 90
eISSN - 1520-6777
pISSN - 0733-2467
DOI - 10.1002/nau.24067
Subject(s) - nocturia , medicine , lower urinary tract symptoms , distress , confirmatory factor analysis , overactive bladder , exploratory factor analysis , physical therapy , urinary incontinence , urge incontinence , genitourinary system , gynecology , urinary system , clinical psychology , psychometrics , urology , prostate , alternative medicine , structural equation modeling , statistics , mathematics , pathology , cancer
Aims To develop a representative, self‐report assessment of lower urinary tract symptoms (LUTS) for men and women, the symptoms of Lower Urinary Tract Dysfunction Research Network Symptom Index‐29 (LURN SI‐29). Methods Women and men seeking treatment for LUTS at one of six academic medical centers in the US were assessed at baseline, 3‐month and 12‐month intervals. Twelve‐month data on 78 LURN SI‐29 items were analyzed among 353 women and 420 men using exploratory factor analysis (EFA), with factor structure confirmed using confirmatory factor analysis (CFA). Internal consistency, reliability, and validity of the five developed scales were evaluated by assessing correlations with the American Urological Association Symptom Index (AUA‐SI), the genitourinary pain index (GUPI), and the Pelvic Floor Distress Inventory‐20 (PFDI‐20), and by examining expected sex differences in scores. Results EFA results (n = 150 women; 150 men) produced an interpretable eight‐factor solution, with three of the factors comprised of dichotomous items addressing LUTS‐associated sensations. The remaining five factors, confirmed with CFA in an independent sample of 473 participants, produced five scales: incontinence, urgency, voiding difficulty, bladder pain, and nocturia. Subscales and total LURN SI‐29 scores were correlated as expected with AUA‐SI, GUPI, and PFDI‐20. LURN SI‐29 scores also performed as expected in differentiating men from women based upon clinically expected differences, with men reporting more voiding difficulties and nocturia, and women reporting more urgency and incontinence. Conclusions The LURN SI‐29 questionnaire has the potential to improve research and clinical outcome measurement for both men and women with LUTS.