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Collagen content in the bladder of men with LUTS undergoing open prostatectomy: A pilot study
Author(s) -
Averbeck Marcio A.,
De Lima Nelson G.,
Motta Gabriela A.,
Beltrao Lauro F.,
Abboud Filho Nury J.,
Rigotti Clarice P.,
Dos Santos William N.,
dos Santos Steven K.J.,
Da Silva Luis F.B.,
Rhoden Ernani L.
Publication year - 2018
Publication title -
neurourology and urodynamics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.918
H-Index - 90
eISSN - 1520-6777
pISSN - 0733-2467
DOI - 10.1002/nau.23418
Subject(s) - medicine , lower urinary tract symptoms , urology , bladder outlet obstruction , prostate , open prostatectomy , prostatectomy , international prostate symptom score , prostate cancer , neck of urinary bladder , urinary bladder , cancer
Aims To evaluate the collagen content in the bladder wall of men undergoing open prostate surgery. Methods From July 2014 to August 2016, men aged ≥ 50 years, presenting LUTS and undergoing open prostate surgery due to benign prostatic enlargement (BPE) or prostate cancer were prospectively enrolled. Preoperative assessment included validated questionnaires (IPSS and OAB‐V8), lower urinary tract ultrasound, and urodynamics. Bladder biopsies were obtained during open prostatectomy for determination of collagen content (sirius red‐picric acid stain; polarized light analysis). Collagen to smooth muscle ratio (C/M) in the detrusor was measured and its relationship with preoperative parameters was investigated. The level of significance was P < 0.05. Results Thirty‐eight consecutive patients were included in this pilot study. Mean age was 66.36 ± 6.44 years and mean IPSS was 11.05 ± 8.72 points. Men diagnosed with diabetes mellitus (DM2) were found to have higher collagen content in the bladder wall when compared to non‐diabetic patients (17.71 ± 6.82% vs 12.46 ± 5.2%, respectively; P = 0.024). Reduced bladder compliance was also marker for higher collagen content ( P = 0.042). Bladder outlet obstruction (BOO) was not a predictor of increased collagen deposition in the bladder wall ( P = 0.75). Patients with PVR ≥ 200 mL showed a higher collagen to smooth muscle ratio in the bladder wall ( P = 0.036). Conclusions DM2 and urodynamic parameters, such as increased PVR and reduced bladder compliance, were associated with higher collagen content in the bladder wall of men with LUTS.