Premium
Transcutaneous posterior tibial nerve electrostimulation with low dose trospium chloride: Could it be used as a second line treatment of overactive bladder in females
Author(s) -
Abulseoud Amr,
Moussa Ahmed,
Abdelfattah Gaber,
Ibrahim Ibrahim,
Saba Emmanuel,
Hassouna Mohamed
Publication year - 2018
Publication title -
neurourology and urodynamics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.918
H-Index - 90
eISSN - 1520-6777
pISSN - 0733-2467
DOI - 10.1002/nau.23361
Subject(s) - medicine , overactive bladder , urology , quality of life (healthcare) , tibial nerve , anesthesia , stimulation , nursing , alternative medicine , pathology
Aim To evaluate the effect of adding low dose trospium chloride with transcutaneous posterior tibial nerve stimulation (TPTNS) in the treatment of overactive bladder (OAB) in females after failure of behavioral therapy. Methods We randomized 30 women with OAB, in two groups: G I received 30 min TPTNS, three times a week; GII received TPTNS plus 20 mg trospium chloride daily. OAB Symptom Score questionnaire (OABSS), Incontinence Impact Questionnaire‐short form 7 (IIQ‐7), 3 day voiding diary and urodynamics at weeks 0 and 8 were evaluated. Results The groups were similar before treatment. Eight weeks after treatment, the mean OABSS decreased significantly to 8.53 ± 1.30 for group II vs 10.0 ± 2.0 for GI ( P < 0.024). The mean IIQ‐7 score decreased significantly to 51.86 ± 17.26 in group I vs 31.99 ± 9.26 in group II ( P < 0.001). Before treatment, 11 (73.3%) and 4 (26.7%) patients in each group had moderate and poor quality of life (QoL), respectively. After treatment, 6 (40%) and 14 (93.3%) had good QoL, 7 (46.7%) and 1 (6.7%) had moderate QoL in GI and GII, respectively. Two (13.3%) patients in GI had poor QoL. The mean frequency was reduced to 8.60 ± 0.83 vs 10.60 ± 2.32 for GII and GI respectively ( P = 0.006). The cystometric capacity increased from 263.40 ± 50.45 to 377.80 ± 112.92 mL ( P = 0.001) for GII vs 250.13 ± 56.24 to 296.40 ± 99.0 mL ( P = 0.026) for GI. Conclusion TPTNS combined with low dose trospium chloride proved to be more effective than TPTNS alone in the treatment of OAB in females.