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Metabolites and microbial composition of stool of women with fecal incontinence: Study design and methods
Author(s) -
Arya Lily A.,
Richter Holly E.,
Jelovsek Eric,
Gantz Marie,
Cichowski Sara,
Zyczynski Halina,
Dyer Keisha,
Siddiqui Nazema,
Carberry Cassandra,
Broeckling Corey,
Morrow Casey,
Kashyap Purna,
Meikle Susie
Publication year - 2018
Publication title -
neurourology and urodynamics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.918
H-Index - 90
eISSN - 1520-6777
pISSN - 0733-2467
DOI - 10.1002/nau.23360
Subject(s) - medicine , fecal incontinence , feces , pelvic floor , observational study , biofeedback , constipation , physical therapy , surgery , microbiology and biotechnology , biology
Aims This paper aims to report the rationale, design, and the specific methodology of an ongoing nested observational study that will determine the association of the metabolite and microbial composition of stool with fecal incontinence (FI). Methods Eligible cases are participants with FI enrolled in the Controlling Anal Incontinence in women by Performing Anal Exercises with Biofeedback or Loperamide (CAPABLe) trial, a Pelvic Floor Disorders Network trial across eight clinical centers in the United States. Women of similar age without FI in the last year served as controls. All subject collected stool samples at the baseline and 24‐week visit at home using a standardized collection method. Samples were shipped to and stored at centralized laboratories. Results Specimen collection commenced December 2014 and was completed in May 2016. Fecal water and DNA has been extracted and is currently being analyzed by targeted metabolic profiling for stool metabolites and 16S rRNA gene sequencing for stool microbiota. Conclusions This article describes the rationale and design of a study that could provide a paradigm shift for the treatment of FI in women.

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