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The effect of intradetrusor botulinum neurotoxin type A on urinary NGF, TGF BETA‐1, TIMP‐2 levels in children with neurogenic detrusor overactivity due to myelodysplasia
Author(s) -
Top Tuncay,
Sekerci Cagri Akin,
IsbilenBasok Banu,
Tanidir Yiloren,
Tinay Ilker,
Isman Ferruh Kemal,
Akbal Cem,
Simsek Ferruh,
Tarcan Tufan
Publication year - 2017
Publication title -
neurourology and urodynamics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.918
H-Index - 90
eISSN - 1520-6777
pISSN - 0733-2467
DOI - 10.1002/nau.23207
Subject(s) - medicine , urinary system , nerve growth factor , urine , urology , clinical significance , statistical significance , prospective cohort study , transforming growth factor , receptor
Aims The aim of this study was to determine the value of urine nerve growth factor (NGF), transforming growth factor beta 1 (TGF‐Beta‐1), tissue inhibitor of matrix metalloproteinase 2 (TIMP‐2) levels to predict the urodynamic profile before and after botulinum neurotoxin type A (BoNT‐A) treatment in children with myelodysplasia. Methods This prospective study included 15 children with myelodysplasia who underwent intradetrusor BoNT‐A injections due to neurogenic detrusor overactivity (NDOA). Urine samples of each child were collected before and after BoNT‐A injections, specifically at the first and third postoperative months. Urine samples were analyzed with ELISA method and NGF, TGF‐Beta‐1, and TIMP‐2 levels were measured. Urine marker levels and clinical findings were assessed for statistical significance with Wilcoxon Signed Ranks Test and Friedman Test. Results A total of 15 children (5 boys and 10 girls) were assigned as the study group. Mean age of the patients was 7.1 ± 2.5 years (range 2.5‐11). A statistically significantly decline was observed in urinary TGF‐Beta‐1 and NGF levels following BoNT‐A injections, compared to the preoperative levels ( P < 0.05). TIMP‐2 levels also tend to decrease following BoNT‐A injections but this was not statistically significant compared to the preoperative levels. Conclusion This preliminary study, suggests urinary TGF‐Beta‐1 and NGF as a potent marker in children with NDOA, as they decline following BoNT‐A injection. Further studies are needed in identifying their special role in assessing treatment success after invasive interventions.