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Effects of pulsed‐radiofrequency neuromodulation on the rat with overactive bladder
Author(s) -
Jen En,
Hsieh TsungHsun,
Lu TsungChe,
Chen MengChao,
Lee FuJung,
Lin ChihTing,
Chen ShihChing,
Chu PeiYi,
Peng ChihWei,
Lin ChiiWann
Publication year - 2017
Publication title -
neurourology and urodynamics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.918
H-Index - 90
eISSN - 1520-6777
pISSN - 0733-2467
DOI - 10.1002/nau.23183
Subject(s) - medicine , overactive bladder , urology , stimulation , neuromodulation , pulsed radiofrequency , pudendal nerve , sacral nerve stimulation , pelvic pain , urinary bladder , pelvic floor , anesthesia , surgery , pain relief , pathology , alternative medicine
Aim To quantify the effects of pulsed radiofrequency (PRF) electrical stimulations of the pudendal and pelvic nerves on the bladder function of rats with detrusor overactivity. Methods All rats were pretreated with a continuous transvesical infusion of 0.5% acetic acid (AA) for inducing detrusor overactivity. Intravesical pressure was recorded using cysometrography (CMG) during the continuous transvesical infusion to examine the effects of PRF electrical stimulation of the pudendal and pelvic nerves individually. In addition, the activity of caspase‐3, an apoptosis marker, in the pelvic nerve was examined to evaluate the impact of PRF on nerve injury. Results According to the first CMG recording, AA treatment significantly reduced bladder capacity (BC) and intercontraction interval (ICI) to 65% and 66% of the corresponding control values, respectively. Subsequently, PRF electrical stimulation of the pelvic nerve inhibited AA‐induced detrusor overactivity and significantly increased BC to approximately 102‐110% and ICI to 79‐92%; these effects persisted for at least 4 h. Furthermore, PRF did not cause significant neural damage to the target stimulated nerves, as demonstrated by caspase‐3 activity. Conclusion PRF electrical stimulation of pelvic nerves exerted a long‐lasting effect of suppressing AA‐induced detrusor overactivity. This modality can be used as an alternative approach for improving bladder continence in patients with overactive bladder syndrome.