z-logo
Premium
Long‐term efficacy of a combination therapy with an anticholinergic agent and an α1‐blocker for patients with benign prostatic enlargement complaining both voiding and overactive bladder symptoms: A randomized, prospective, comparative trial using a urodynamic study
Author(s) -
Matsukawa Yoshihisa,
Takai Shun,
Funahashi Yasuhito,
Kato Masashi,
Yamamoto Tokunori,
Gotoh Momokazu
Publication year - 2017
Publication title -
neurourology and urodynamics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.918
H-Index - 90
eISSN - 1520-6777
pISSN - 0733-2467
DOI - 10.1002/nau.23013
Subject(s) - silodosin , medicine , overactive bladder , anticholinergic , urology , prospective cohort study , anticholinergic agents , urinary urgency , anesthesia , lower urinary tract symptoms , prostate , alternative medicine , pathology , cancer
Aims We evaluated long‐term efficacy and safety of a combination therapy (CT) with an anticholinergic agent and an α1‐blocker for patients with benign prostatic enlargement (BPE) complaining of voiding and overactive bladder (OAB) symptoms, in comparison with those of α1‐blocker monotherapy (MT), by conducting a urodynamic study (UDS). Methods This was a randomized prospective study involving 120 outpatients with untreated BPE associated with urinary urgency at least once per week and OABSS of ≥3. The patients were randomly assigned to receive MT with silodosin at 8 mg/day or CT with silodosin at 8 mg/day and propiverine at 20 mg/day. Changes in parameters from baseline to 12 weeks and 1 year after administration were assessed based on IPSS, IPSS‐QOL, OABSS, and voiding and storage functions as measured by UDS. Results In efficacy analysis, 53 patients with MT and 51 with CT were included. Although mean IPSS and OABSS significantly improved in both groups, the CT group showed statistically significant improvement in OABSS (−3.4 in CT, −2.4 in MT, P  = 0.04), IPSS‐QOL (−1.9, −1.2, P  = 0.01), and OAB‐urgency score (−1.8, −1.2, P  < 0.01) at the long‐term evaluation. In storage function, both groups showed significant improvements, but the CT group demonstrated a greater improvement in terms of disappearance rate of detrusor overactivity (54.5% in CT, 34.2% in MT, P  = 0.07) and bladder capacity (+61 mL, +33 mL, P  = 0.02). Conclusions Long‐term combination treatment with silodosin and propiverine was effective and safe for BPE patients with voiding and OAB symptoms. Neurourol. Urodynam. 36:748–754, 2017 . © 2016 Wiley Periodicals, Inc.

This content is not available in your region!

Continue researching here.

Having issues? You can contact us here
Empowering knowledge with every search

Discover

Journals

Proceedings

Books

Explore

Engineering & Computer Science

Health & Medical Sciences

Humanities, Literature & Arts

Life Sciences & Earth Sciences

Physics & Mathematics

Social Sciences

Chemical & Material Sciences

Business, Economics & Management