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Brain activity on fMRI associated with urinary bladder filling in patients with a complete spinal cord injury
Author(s) -
Krhut Jan,
Tintera Jaroslav,
Bilkova Karolina,
Holy Petr,
Zachoval Roman,
Zvara Peter,
Blok B.
Publication year - 2017
Publication title -
neurourology and urodynamics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.918
H-Index - 90
eISSN - 1520-6777
pISSN - 0733-2467
DOI - 10.1002/nau.22901
Subject(s) - medicine , parabrachial nucleus , functional magnetic resonance imaging , spinal cord , thalamus , spinal cord injury , insular cortex , urinary system , magnetic resonance imaging , anesthesia , anatomy , central nervous system , radiology , psychiatry
Objective Patients with complete spinal cord injury (SCI) may maintain some perception of bladder fullness. The aim of the study was to evaluate brain activation arising from anticipated extraspinal sensory pathways. Methods Fourteen patients ages 24–54 years were enrolled, all having experienced a complete SCI (ASIA A) at C7 to T5 an average of 17 months before study entry. Urodynamic equipment was used for repeated bladder filling and detrusor activity evaluation. All functional magnetic resonance imaging measurements were performed using a Siemens Trio 3T scanner with the GRE‐EPI sequence (field of view = 192 × 192 mm, voxel 3 × 3 × 3 mm, TR/TE = 3000/30 ms, 45 slices). Nine hundred dynamic scans were acquired over 45 min. Statistical analysis was done in SPM8 using a general linear model. Statistics using t ‐tests were thresholded at P = 0.001. Results We excluded results from two patients because of activation artifacts. In 8 of 12 patients, significant brain activity was observed during urinary bladder filling. We found significant activation clusters at the nucleus of the solitary tract (NTS) (3/8), parabrachial nucleus (PBN) (4/8), hypothalamus (4/8), thalamus (6/8), amygdala (7/8), insular lobe (5/8), anterior cingulate gyrus (5/8), and prefrontal cortex (8/8). Activations in nuclei involved in afferents likely from the vagal nerve (NTS and PBN) correlated significantly with reported bladder sensations. Conclusions These data suggest that extraspinal sensory pathways may develop following SCI and that vagal nerve may play a role in re‐innervation of the urinary bladder. Neurourol. Urodynam. 36:155–159, 2017 . © 2015 Wiley Periodicals, Inc.