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Intravesical treatment with cis‐urocanic acid improves bladder function in rat model of acute bladder inflammation
Author(s) -
Konkol Yvonne,
Bernoulli Jenni,
Streng Tomi,
Jääskeläinen Katarina,
Laihia Jarmo,
Leino Lasse
Publication year - 2016
Publication title -
neurourology and urodynamics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.918
H-Index - 90
eISSN - 1520-6777
pISSN - 0733-2467
DOI - 10.1002/nau.22818
Subject(s) - medicine , urination , urology , irritation , inflammation , urinary bladder , urothelium , urinary system , immunology
Aims The aim was to study the effect of intravesically instilled cis‐urocanic acid (cis‐UCA) on bladder function in an experimental rat model of acute bladder inflammation. Hyaluronic acid (HA) was used as a comparator compound. Methods Bladder irritation was induced in female rats by intravesical hydrochloric acid (HCl) infusion. Vehicle, 0.5% HA, or 2% cis‐UCA solutions were infused intravesically twice a day for three consequent days. On the fourth day, urodynamical measurements were performed, the animals were sacrificed, and the bladders were removed for histopathological assessment. Results HCl treatment caused significant impairment of bladder function indicated by decreased micturition intervals and voided urine volumes and induced severe voiding dysfunction observed as occurrence of overflow incontinence. These functional changes were accompanied by increased bladder weight, hemorrhage, and infiltration of inflammatory cells into the urothelium. Intravesical cis‐UCA treatment recovered bladder function by significantly prolonging the micturition interval, increasing the voided volume, and reducing the occurrence of overflow incontinence. All these changes were comparable to the effects of HA. Conclusions Intravesical administration of cis‐UCA was able to partially recover bladder function impaired by chemical irritation. Cis‐UCA may offer a novel intravesical treatment option in some inflammatory conditions of the bladder. Neurourol. Urodynam. 35:786–791, 2016 . © 2015 Wiley Periodicals, Inc.