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Frequency analysis of urinary bladder pre‐voiding activity in normal and overactive rat detrusor
Author(s) -
Clavica Francesco,
Choudhary Mahipal,
van Asselt Els,
van Mastrigt Ron
Publication year - 2015
Publication title -
neurourology and urodynamics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.918
H-Index - 90
eISSN - 1520-6777
pISSN - 0733-2467
DOI - 10.1002/nau.22664
Subject(s) - overactive bladder , medicine , urology , urinary bladder , urinary system , urinary incontinence , pathology , alternative medicine
Aims To test the hypothesis that voiding in anesthetized rats is preceded by recurrent changes in the pattern of bladder pressure. To explore the use of frequency analysis as an analytical tool for automatically detecting these changes and to provide quantitative data on bladder pre‐voiding activity. Methods We developed an algorithm, based on frequency analysis, to study bladder pressure during the filling phase in anesthetized rats. Two applications of the algorithm were tested: (i) as a predictor of a voiding contraction with alarms generated which would make conditional nerve stimulation to prevent incontinence possible; and (ii) as a new index to quantify rapid pressure transients in normal and overactive detrusor conditions (i.e., induced by acetic acid instillation into the bladder). Results The results show that a very high percentage (∼90%) of the alarms was generated by the algorithm within 100 sec before voiding. The index of rapid transients and the bladder volume before voiding were respectively ∼13% less and ∼42% less in acetic acid. Conclusions We have shown that a simple algorithm, based on frequency analysis of bladder pressure, can be used to predict voiding and to provide quantitative data on non‐voiding bladder activity and its changes due to pathology. Although the results refer to anesthetized rats, they are promising and warrant further urodynamic investigation to identify if similar patterns occur in non‐anesthetized rats and in humans. Neurourol. Urodynam. 34:794–799, 2015 . © 2014 Wiley Periodicals, Inc.