Premium
Relationship between asymmetric dimethylarginine and nocturia in the general elderly population: The HEIJO‐KYO cohort
Author(s) -
Obayashi Kenji,
Saeki Keigo,
Kurumatani Norio
Publication year - 2015
Publication title -
neurourology and urodynamics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.918
H-Index - 90
eISSN - 1520-6777
pISSN - 0733-2467
DOI - 10.1002/nau.22647
Subject(s) - nocturia , medicine , asymmetric dimethylarginine , odds ratio , logistic regression , confidence interval , population , univariate analysis , international prostate symptom score , endocrinology , urology , multivariate analysis , lower urinary tract symptoms , urinary system , prostate , biochemistry , chemistry , cancer , environmental health , amino acid , arginine
Aims To evaluate the relationship between asymmetric dimethylarginine (ADMA) and nocturia. Methods A total of 862 community‐based elderly individuals were examined in this cross‐sectional study (mean age, 72.1 years). We measured nocturnal void frequency and serum ADMA levels. Nocturia was ascertained for a frequency of two or more nocturnal voids. Results Nocturia was observed in 262 (30.4%) participants. Univariate logistic regression models revealed a significant association between prevalent nocturia and ADMA levels (crude odds ratio [OR], 1.556 [2nd vs. 1st tertile]; 95% confidence interval [CI], 1.066–2.270; P = 0.022; crude OR, 2.114 [3rd vs. 1st tertile]; 95% CI, 1.453–3.072; P < 0.001). Univariate logistic regression models also revealed marginal to significant associations between prevalent nocturia and age, gender, calcium channel blocker use, nitric oxide‐related drug use, diabetes, estimated glomerular filtration rate, insomnia, benign prostatic hyperplasia, overnight urine volume, and endogenous melatonin levels. In the multivariate model simultaneously adjusted for the former variables, higher ADMA levels were significantly associated with higher OR for nocturia (adjusted OR, 1.556 [3rd vs. 1st tertiles]; 95% CI, 1.010–2.397; P = 0.045). Conclusion Serum ADMA levels, an endogenous inhibitor of nitric oxide synthase, are significantly associated with prevalent nocturia in the general elderly population. Neurourol. Urodynam. 34:769–773, 2015 . © 2014 Wiley Periodicals, Inc.