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Chapter 2: Pathophysiology of neurogenic detrusor overactivity and the symptom complex of “Overactive bladder”
Author(s) -
Chapple Christopher
Publication year - 2014
Publication title -
neurourology and urodynamics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.918
H-Index - 90
eISSN - 1520-6777
pISSN - 0733-2467
DOI - 10.1002/nau.22635
Subject(s) - medicine , overactive bladder , afferent , efferent , urinary system , basic science , pathophysiology , neuroscience , central nervous system , detrusor muscle , neuromodulation , urinary bladder , urology , pathology , psychology , alternative medicine
It is now clearly recognized that the function of the lower urinary tract represents a complex interaction between the bladder and its outlet, acting under the control of the central nervous system. While in the past attention has principally focused on the motor (efferent) control of the bladder, sensory (afferent) innervation is now known to be an important therapeutic target. This change in emphasis is strongly supported by both basic science and clinical evidence demonstrating the efficacy of therapy directed at the afferent system. This chapter summarizes the neurophysiological control mechanism that underpins normal lower urinary tract function, emphasizing the importance of the afferent system as a potential therapeutic target. Neurourol. Urodynam. 33:S6–S13, 2014 . © 2014 Wiley Periodicals, Inc.