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Increased risk of ischemic stroke among women with bladder pain syndrome/interstitial cystitis: A cohort study from Taiwan
Author(s) -
Chung ShiuDong,
Xirasagar Sudha,
Lin ChingChun,
Ling Wells,
Li HsienChang,
Lin HerngChing
Publication year - 2015
Publication title -
neurourology and urodynamics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.918
H-Index - 90
eISSN - 1520-6777
pISSN - 0733-2467
DOI - 10.1002/nau.22515
Subject(s) - medicine , stroke (engine) , hazard ratio , atrial fibrillation , etiology , interstitial cystitis , cohort study , confidence interval , cohort , proportional hazards model , urinary system , mechanical engineering , engineering
Aim Vascular factors are proposed in the etiology of bladder pain syndrome/interstitial cystitis (BPS/IC). In this study, we investigated the risk of stroke among women following a diagnosis of BPS/IC over 3 years of follow‐up, compared to controls without a BPS/IC diagnosis. Methods This retrospective cohort study used data retrieved from the Taiwan “Longitudinal Health Insurance Database 2000.” We identified 847 women who received a diagnosis of BPS/IC between January 1, 2001 and December 31, 2008 (study group) and 4,235 comparison women (women without a BPS/IC diagnosis matched on age and other selected demographic variables. All subjects were tracked for 3 years following the index date to identify those who received a diagnosis of stroke during follow‐up. Results The stroke incidence rate was 20.86 (95% confidence interval (CI): 15.78–27.07) and 11.65 (95% CI: 9.88–13.64) per 1,000 person‐years among the study and comparison cohorts, respectively. Cox regression analysis showed a stroke hazard ratio (HR) of 1.52 (95% CI: 1.09–2.14) in the BPS/IC group relative to the comparison group over 3‐year follow‐up, after adjusting for hypertension, diabetes, coronary heart disease, atrial fibrillation, hyperlipidemia, and chronic kidney disease. The adjusted HR of ischemic stroke was 1.52 (95% CI: 1.02–2.27). However, there was no significant difference between the two groups in hemorrhagic stroke risk. Conclusions Our study demonstrates an association between BPS/IC and a subsequent ischemic stroke diagnosis among women in Taiwan. Neurourol. Urodynam. 34:44–49, 2015 . © 2013 Wiley Periodicals, Inc.