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The relationship between cerebral white matter hyperintensities and lower urinary tract function in a population based, geriatric cohort
Author(s) -
Wehrberger Clemens,
Jungwirth Susanne,
Fischer Peter,
Tragl KarlHeinz,
Krampla Wolfgang,
Marlies Wehrberger,
Madersbacher Stephan
Publication year - 2014
Publication title -
neurourology and urodynamics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.918
H-Index - 90
eISSN - 1520-6777
pISSN - 0733-2467
DOI - 10.1002/nau.22419
Subject(s) - nocturia , medicine , hyperintensity , lower urinary tract symptoms , cohort , prospective cohort study , population , urinary incontinence , urinary system , magnetic resonance imaging , surgery , radiology , prostate , environmental health , cancer
White matter hyperintensities (WHM) in cerebral MRI‐scan have been suspected to be involved in the pathogenesis for geriatric LUTS. Aim of this study was to investigate this association in a geriatric cohort. Materials and Methods The VITA‐study is a prospective, population‐based study initiated 2000/2001. All inhabitants of a well‐defined area in Vienna aged 75 years were recruited and underwent detailed regular visits including cerebral MRI‐scans. Subcortical and periventricular WMHs were classified according to the Fazekas‐classification. In 2010, all subjects alive were contacted to complete the Bristol LUTS questionnaire. Results Two hundred seventeen participants (75 men, 142 women), all 85 years old, entered this analysis. Urgency, frequency, and nocturia was present in 39 (50.7%), 53 (52%), and 55 (73.3%) men and 79 (55.6%), 81 (78.2%), and 68 (47.9%) women, respectively. OAB symptoms were seen in 55% of women and 50% of men. At baseline, WMH were present in 68.2% and this percentage increased to 85.7% at the most recent follow‐up. Several symptoms were more prevalent in participants without WMH as compared to those with WMH, (urgency: 71% vs. 53%, P = 0.06, nocturia: 77% vs. 53%, P = 0.01: OAB‐symptoms: 71% vs. 51%, P = 0.05. Only frequency was more prevalent in participants with WMH (77% vs. 68%, P = 0.27). In general, sub‐categorization into periventricular and subcortical WMH confirmed these data. Furthermore the amount of WMH‐burden did not correlate to LUT dysfunction. Conclusion This study failed to demonstrate a clear association between several aspects of LUTS and WMH in a rather healthy, population‐based 85‐year‐old cohort. Neurourol. Urodynam. 33:431–436, 2014 . © 2013 Wiley Periodicals, Inc.