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Obstructive sleep apnea increases the risk of bladder pain syndrome/interstitial cystitis: A population‐based matched‐cohort study
Author(s) -
Chung ShiuDong,
Lin ChingChun,
Liu ShihPing,
Lin HerngChing
Publication year - 2014
Publication title -
neurourology and urodynamics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.918
H-Index - 90
eISSN - 1520-6777
pISSN - 0733-2467
DOI - 10.1002/nau.22401
Subject(s) - medicine , interstitial cystitis , hazard ratio , obstructive sleep apnea , population , irritable bowel syndrome , sleep apnea , fibromyalgia , proportional hazards model , cohort study , cohort , confidence interval , urinary system , environmental health
Aims Previous studies indicated a possible association between bladder pain syndrome/interstitial cystitis (BPS/IC) and sleep disorders including sleep abnormalities with delayed onset of sleep, waking up before needed, and snoring. Nevertheless, no previous study has reported the association between obstructive sleep apnea (OSA) and BPS/IC. In this retrospective cohort study, we examined the risk of BPS/IC among subjects with OSA during a 3‐year follow‐up in Taiwan using a population‐based dataset. Methods This study comprised 2,940 study subjects with OSA, and 29,400 randomly selected comparison subjects. We individually followed‐up each sampled subject (n = 32,340) for a 3‐year period to identify those subjects who subsequently received a diagnosis of BPS/IC. A Cox proportional hazards regression model was constructed to estimate the risk of subsequent BPS/IC following a diagnosis of OSA. Results Incidences of BPS/IC during the 3‐year follow‐up period were 13.61 (95% confidence interval [CI] = 7.37–23.13) and 3.60 (95% CI = 2.06–4.39) for subjects with and those without OSA, respectively. After adjusting for diabetes, hypertension, coronary heart disease, obesity, hyperlipidemia, chronic pelvic pain, irritable bowel syndrome, fibromyalgia, chronic fatigue syndrome, depression, panic disorder, migraines, sicca syndrome, allergies, endometriosis, asthma, tobacco use disorder, and alcohol abuse, the stratified Cox proportional hazards regressions revealed that the hazard ratio for BPS/IC among subjects with OSA was 3.71 (95% CI = 1.81–7.62, P < 0.001) that of comparison subjects. Conclusions This study provides epidemiological evidence of a link between OSA and a subsequent BPS/IC diagnosis. We suggest that clinical practitioners treating subjects with OSA be alert to urinary complaints in this population. Neurourol. Urodynam. 33:278–282, 2014 . © 2013 Wiley Periodicals, Inc.