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Receiver operating characteristic analysis of sphincter electromyography for parkinsonian syndrome
Author(s) -
Yamamoto Tatsuya,
Sakakibara Ryuji,
Uchiyama Tomoyuki,
Yamaguchi Chiharu,
Nomura Fumio,
Ito Takashi,
Yanagisawa Mitsuru,
Yano Masashi,
Awa Yusuke,
Yamanishi Tomonori,
Hattori Takamichi,
Kuwabara Satoshi
Publication year - 2012
Publication title -
neurourology and urodynamics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.918
H-Index - 90
eISSN - 1520-6777
pISSN - 0733-2467
DOI - 10.1002/nau.22208
Subject(s) - medicine , progressive supranuclear palsy , receiver operating characteristic , atrophy , electromyography , duration (music) , area under the curve , audiology , physical medicine and rehabilitation , art , literature
Aims We performed receiver operating characteristic (ROC) analysis to determine the ability of sphincter electromyography (EMG) to distinguish multiple system atrophy (MSA) from other parkinsonisms. The following was determined: (1) the appropriate motor unit potential (MUP) parameter among duration, phase, and amplitude; (2) the desirable parameter of our duration criteria; that is, more than 20% MUPs having >10 ms duration (criteria a) or mean duration >10 ms (criteria b). Methods We retrospectively reviewed 441 case records where sphincter EMG were performed in patients with parkinsonian syndromes: MSA, n = 263; Parkinson's disease, n = 129; dementia with Lewy bodies, n = 25; and progressive supranuclear palsy, n = 24. We performed ROC analysis of the data sets. Results The area under the curve used to differentiate MSA from other parkinsonian syndromes was 0.68 in duration, 0.57 in phase, and 0.51 in amplitude, respectively; these values were statistically significant. With regard to our duration criteria, area under the curve was 0.69 for the average duration of MUPs (criteria b) and 0.67 for percentage of MUPs of duration >10 ms (criteria a); these values were also statistically significant. Conclusions This study suggests that duration is appropriate parameter for the differentiation of MSA. However, the area under the curve of the mean duration was insufficient to confirm the diagnosis; sphincter EMG should be used as a supportive diagnostic tool for the diagnosis of MSA. Neurourol. Urodynam. 31:1128–1134, 2012. © 2012 Wiley Periodicals, Inc.