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Effect of the anticonvulsant medications Pregabalin and Lamotrigine on urodynamic parameters in an animal model of neurogenic detrusor overactivity
Author(s) -
Loutochin Oleg,
Afraa Tala Al,
Campeau Lysanne,
Mahfouz Wally,
Elzayat Ehab,
Corcos Jacques
Publication year - 2012
Publication title -
neurourology and urodynamics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.918
H-Index - 90
eISSN - 1520-6777
pISSN - 0733-2467
DOI - 10.1002/nau.21214
Subject(s) - lamotrigine , medicine , pregabalin , anticonvulsant , anesthesia , animal study , detrusor muscle , pharmacology , urology , epilepsy , urinary bladder , surgery , psychiatry
Aims To assess the effects of different doses and treatment durations of Pregabalin and Lamotrigine on the urodynamic parameters of an animal model of neurogenic detrusor overactivity (NDO). Materials and Methods Ninety rats were used; six as normal controls and the remaining 84 were divided as follows: Six “paraplegic controls,” 6 “paraplegic‐vehicle controls,” and the remaining 72 divided into two equal groups. Group 1 was divided into six subgroups; Pregabalin was given in doses of 10 mg/kg, 20 mg/kg, or 30 mg/kg for 1 or 2 weeks. Group 2 was similarly subdivided; Lamotrigine was given in doses of 1.5 mg/kg, 3 mg/kg, or 6 mg/kg for 1 or 2 weeks. Results All paraplegic controls developed NDO within 3 weeks from spinalization. Their baseline bladder pressure (BBP) 19 ± 4.4 cmH 2 O, detrusor pressure at maximum capacity (DPMaxC) 47.6 ± 4.3 cmH 2 O, bladder capacity (BC) 0.45 ± 0.1 ml, and frequency of detrusor overactivity (FDO) 3.7 ± 0.9/min. Both Pregabalin and Lamotrigine produced significant improvement. Urodynamic values in those treated with 20 mg Pregabalin for 1 or 2 weeks were: BBP 11.7 ± 1.3 and 9 ± 0.2 cmH 2 O, BC 0.6 ± 0.1 and 0.7 ± 0.01 ml, DPMaxC 17.3 ± 4.0 and 23 ± 2.6 cmH 2 O, FDO 2.1 ± 0.2/min and 1.7 ± 0.1/min. Urodynamic values in those treated with 3 mg/kg Lamotrigine for 1 or 2 weeks were: BBP 9.7 ± 2.2 and 8.6 ± 1.9 cmH 2 O, DPMaxC 17.2 ± 1.8 and 29 ± 1.2 cmH 2 O, BC 0.7 ± 0.1 and 0.8 ± 0.1 ml, FDO 1.9 ± 0.2/min and 1.9 ± 0.2/min ( P < 0.001). Conclusions Pregabalin and Lamotrigine may represent novel alternative treatments of NDO. Clinical trials remain to be performed. Neurourol. Urodynam. 31:1197–1202, 2012. © 2012 Wiley Periodicals, Inc.