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The effect of biological and synthetic meshes on vaginal smooth muscle cell proliferation
Author(s) -
Gualtieri Marc,
Zhang Yanping,
Candiotti Keith,
Yavagal Sujata,
Medina Carlos A.,
Takacs Peter
Publication year - 2011
Publication title -
neurourology and urodynamics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.918
H-Index - 90
eISSN - 1520-6777
pISSN - 0733-2467
DOI - 10.1002/nau.21064
Subject(s) - medicine , cell growth , andrology , surgical mesh , matrix (chemical analysis) , in vitro , urology , surgery , biology , chemistry , hernia , biochemistry , chromatography
Aims To compare the effects of polypropylene mesh or porcine dermal acellular collagen matrix mesh with and without estradiol supplementation on vaginal smooth muscle cells (VaSMC) proliferation. Results Under in vitro culture conditions, VaSMC proliferation was significantly higher in the porcine dermal acellular collagen matrix mesh exposed cells compared to the type I polypropylene mesh exposed cells (relative cell number, mean ± SD, 0.27 ± 0.03 vs. 0.21 ± 0.01, P = 0.03). Under estradiol supplementation cell proliferation in the porcine mesh exposed cells remained significantly higher compared to the polypropylene mesh exposed cells (relative cell number, mean ± SD, 0.27 ± 0.04 vs. 0.15 ± 0.03, P < 0.01). Conclusion The decreased rate of erosion found with the utilization of biological absorbable mesh in vaginal reconstructive surgery may partially be explained by the significantly increased VaSMC proliferation with porcine dermal acellular collagen mesh compared to polypropylene mesh. Neurourol. Urodynam. 30:435–437, 2011. © 2011 Wiley‐Liss, Inc.