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Brain response provoked by different bladder volumes: A near infrared spectroscopy study
Author(s) -
Matsumoto Shinya,
Ishikawa Akira,
Matsumoto Shinichi,
Homma Yukio
Publication year - 2011
Publication title -
neurourology and urodynamics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.918
H-Index - 90
eISSN - 1520-6777
pISSN - 0733-2467
DOI - 10.1002/nau.21016
Subject(s) - medicine , sensation , frontal lobe , cerebral blood flow , urinary system , urinary bladder , urology , functional near infrared spectroscopy , frontal cortex , prefrontal cortex , neuroscience , cognition , psychology , psychiatry
Abstract Aims In order to understand frontal lobe responses in bladder sensation in healthy subjects, we examined the cortical localization of response to the different bladder volumes. Methods Frontal blood flow was measured non‐invasively in 24 resting adults using multi‐channel near infrared spectroscopy (NIRS). Changes in bladder volume were induced by infusing and releasing water from the bladder. Two states of bladder sensation have been induced, “first desire to void” and “strong desire to void. Results NIRS analysis revealed that cerebral responses to bladder sensation were associated with increased levels of oxy‐hemoglobin in the bilateral frontal cortex. The responses became stronger in the state of strong desire to void at enlarged bladder volume ( P < 0.01). These results indicate that bilateral frontal areas are involved in bladder perception related to increased urine volumes in adults. Conclusions The dynamic changes in cerebral blood oxygenation were similar to those assessed in other methodologies such as f‐MRI and PET. This result suggests that NIRS study might be available for investigating the mutual relationship between bladder and brain in patients suffering from neurological problems and urinary tract symptoms. 30:529–535, 2011. © 2011 Wiley‐Liss, Inc.