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Stem cell therapy for stress urinary incontinence
Author(s) -
Nikolavsky Dmitriy,
Chancellor Michael B.
Publication year - 2010
Publication title -
neurourology and urodynamics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.918
H-Index - 90
eISSN - 1520-6777
pISSN - 0733-2467
DOI - 10.1002/nau.20833
Subject(s) - medicine , urinary incontinence , regeneration (biology) , urethral sphincter , urethra , urology , stem cell , stress incontinence , stem cell therapy , urinary system , anatomy , transplantation , microbiology and biotechnology , biology
The rhabdosphincter at the mid urethra is critical for maintaining urinary continence. In a setting of stress urinary incontinence stem cells transplanted into the site of the rhabdosphincter may augment sphincter regeneration and also release trophic factors promoting muscle and nerve integration of this muscle. We hereby review the use of cellular therapy for SUI and our experience with the development of muscle‐derived stem cells (MDSCs). Neurourol. Urodynam. 29:S36–S41, 2010. © 2010 Wiley‐Liss, Inc.