Premium
Antimuscarinics and bladder outlet obstruction: From a contraindication to an indication?
Author(s) -
Athanasopoulos Anastasios
Publication year - 2010
Publication title -
neurourology and urodynamics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.918
H-Index - 90
eISSN - 1520-6777
pISSN - 0733-2467
DOI - 10.1002/nau.20807
Subject(s) - contraindication , medicine , overactive bladder , bladder outlet obstruction , tolterodine , urology , concomitant , urinary retention , discontinuation , intensive care medicine , surgery , alternative medicine , prostate , pathology , cancer
Aim To review if the existing data support the new concept that antimuscarinic agents can be used for the treatment of bladder outlet obstruction (BOO) with coexisting overactive bladder (OAB). Method A literature search of Medline publications (up to 2008) on use of antimuscarinic agents for treatment BOO was performed and all data were presented. All relevant data from published studies in congress abstracts were as well included. Results The existing data show that this treatment effectively improves patient quality of life. Concerns about the possibility of urinary retention were shown to be unfounded. It seems that antimuscarinic agents do not affect voiding pressures and the use of antimuscarinic agents for BOO seems safe. Conclusions The combination of an α‐blocker and antimuscarinic agent for the treatment of BOO with concomitant OAB seems promising. Neurourol. Urodynam. 29:S46–S50, 2010. © 2010 Wiley‐Liss, Inc.