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Tolterodine causes measurable restoration of urethral sensation in women with urge urinary incontinence
Author(s) -
Kenton Kimberly,
Lowenstein Lior,
Brubaker Linda
Publication year - 2010
Publication title -
neurourology and urodynamics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.918
H-Index - 90
eISSN - 1520-6777
pISSN - 0733-2467
DOI - 10.1002/nau.20804
Subject(s) - tolterodine , medicine , interquartile range , urinary incontinence , sensation , urology , urge incontinence , overactive bladder , urinary system , sensory threshold , surgery , psychology , alternative medicine , pathology , neuroscience , biology , cognitive science
& Hypothesis Determine if treatment of urge incontinence with tolterodine results in changes in bladder and/or urethral sensation using Current Perception Threshold (CPT) testing. Methods Women with ≥1 incontinence episode on 7‐day diary were treated with 4 mg of long‐acting tolterodine for 2‐months. At baseline and 2‐months, participants had CPT testing of the urethral and bladder at 3 frequencies 2000, 250, and 5 Hz. Baseline and post‐treatment measures were compared using Wilcoxon Signed Rank Test. Results Seventeen women underwent baseline CPT testing. Four discontinued medication due to side effects and did not have repeated testing. Urethral CPT at 250 Hz was lower after treatment (median 1.3 [Interquartile range .69‐‐2.1] and .75 [.45‐‐1.2], p = .003) and at 5 Hz trended toward a significant decrease (1.1 [1‐‐1.9] and .84 [.32‐‐1.1], p = .06). Conclusions Urethral sensitivity improves after 2‐months of tolterodine, suggesting it may restore urethral sensory nerves in addition to known motor effects. Neurourol. Urodynam. 29:555–557, 2010. © 2009 Wiley‐Liss, Inc.