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Obesity is associated with a more severe overactive bladder disease state that is effectively treated with once‐daily administration of trospium chloride extended release
Author(s) -
Chancellor Michael B.,
Oefelein Michael G.,
Vasavada Sandip
Publication year - 2010
Publication title -
neurourology and urodynamics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.918
H-Index - 90
eISSN - 1520-6777
pISSN - 0733-2467
DOI - 10.1002/nau.20787
Subject(s) - medicine , overactive bladder , overweight , obesity , placebo , population , urinary incontinence , sarcopenic obesity , urology , environmental health , alternative medicine , pathology
Aims Obesity is an established risk factor for urinary incontinence, yet no information exists as to the efficacy of antimuscarinic agents in this population. The goal of this study is to examine the efficacy of once daily trospium chloride (Sanctura™) XR in overweight and obese patients with the overactive bladder syndrome. Methods The primary and secondary end‐points of the 1,165 study subjects from the integrated trospium chloride XR pivotal trials were stratified by World Health Organization (WHO) obesity levels I and II. Results Obesity (WHO level I, II criteria) was associated with a more severe baseline OAB disease state (P < 0.01). Trospium chloride XR was more effective than placebo at reducing the primary endpoints (toilet voids, UUI, P < 0.0001) and at improving the secondary end‐points (percent patients continent and urgency severity, P < 0.0001) for WHO obesity levels I and II. Conclusions Obesity is associated with a more severe OAB disease state. Once daily trospium chloride XR is efficacious in the obese patient with the OAB syndrome. Neurourol. Urodynam. 29:551–554, 2010. © 2009 Wiley‐Liss, Inc.

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