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Dorsal genital nerve stimulation for the treatment of overactive bladder symptoms
Author(s) -
Goldman Howard B.,
Amundsen Cindy L.,
Mangel Jeffrey,
Grill Julie,
Bennett Maria,
Gustafson Kenneth J.,
Grill Warren M.
Publication year - 2008
Publication title -
neurourology and urodynamics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.918
H-Index - 90
eISSN - 1520-6777
pISSN - 0733-2467
DOI - 10.1002/nau.20544
Subject(s) - medicine , overactive bladder , cystometry , adverse effect , percutaneous , stimulation , urinary incontinence , surgery , anesthesia , urology , urinary bladder , alternative medicine , pathology
Aim To evaluate percutaneous placement of electrodes adjacent to the dorsal genital nerve (DGN) and measure the effects of electrical stimulation on symptoms of urge incontinence during 1 week of home use. Methods Prospective, multicenter study. Subjects with urge incontinence underwent percutaneous placement of an electrode using local anesthetic. Test stimulation was applied to confirm electrode placement and cystometry was conducted with and without application of electrical stimulation. A 7‐day testing period with the electrode connected to an external pulse generator was performed and was followed by a 3‐day post‐treatment test period. Bladder diaries, 24 hr pad tests, and adverse event queries were obtained. Results Twenty‐one women were enrolled with an average age of 52.7 years and average duration of incontinence of 6 years. Percutaneous electrode placement required 5–10 min and was well tolerated. There was no relationship between the acute effects of stimulation on cystometry and the results during home use. Pad weight was reduced by ≥ 50% in 13 of 17 subjects (76%) (4 did not complete 24 hr pad testing) and 47% of subjects reported ≥50% reduction in incontinence episodes. Of the subjects who reported severe urgency at baseline, 81% experienced a 50% or greater improvement. Seven subjects experienced nine adverse events ranging from skin irritation to pain and bruising around the electrode exit site. Conclusions Electrodes to stimulate the DGN can be placed percutaneously and a home testing period showed a reduction in overactive bladder symptoms with DGN stimulation. Neurourol. Urodynam. 27:499–503, 2008. © 2007 Wiley‐Liss, Inc.