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Role of urothelial nerve growth factor in human bladder function
Author(s) -
Birder Lori A.,
WolfJohnston Amanda,
Griffiths Derek,
Resnick Neil M.
Publication year - 2007
Publication title -
neurourology and urodynamics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.918
H-Index - 90
eISSN - 1520-6777
pISSN - 0733-2467
DOI - 10.1002/nau.20372
Subject(s) - medicine , nerve growth factor , urothelium , urology , cystometry , human bladder , contractility , urinary bladder , lower urinary tract symptoms , sensation , overactive bladder , endocrinology , pathology , prostate , bladder cancer , psychology , receptor , alternative medicine , cancer , neuroscience
Aims To test whether nerve growth factor (NGF) concentration in human bladder urothelium/suburothelium is related to detrusor overactivity (DO), bladder sensation, detrusor contractility, or other aspects of lower urinary tract function. Materials and Methods Concentration of NGF was measured (using ELISA) in superficial bladder biopsies from 27 women (mean age 52 years, range 22–82) after comprehensive videourodynamics and bladder diary. Approximately half (12/27) showed clear DO and half did not. Results There was no evidence for increased NGF concentration in subjects with DO (association negative by Mann–Whitney test, P = 0.23). NGF was not significantly associated with two measures of detrusor contractility (Spearman's r = −0.29, P = 0.17; r = −0.20, P = 0.33); nor with four measures inversely related to sensation: volume at strong desire to void and maximum capacity on cystometry (r = −0.13, P = 0.53; r = −0.23, P = 0.28), and maximum voided volume and mean daytime voided volume on bladder diary (r = −0.29, P = 0.16; r = −0.16, P = 0.44). It was significantly associated with 24‐hr urine output on bladder diary (Spearman's r = −0.55, P = 0.004). Conclusions Elevated NGF levels in human urothelium/suburothelium are not strongly associated with DO, detrusor contractility or increased bladder sensation. NGF levels are lower in subjects with higher 24‐hr urine output. This observation is consistent with a role for NGF in an active process (trafficking) involved in bladder filling. Neurourol. Urodynam. 26:405–409, 2007. © 2007 Wiley‐Liss, Inc.