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Conscious minipig model for evaluating the lower urinary tract
Author(s) -
Guan Zhichen,
Kiruluta George,
Coolsaet Bo,
Elhilali Mostafa
Publication year - 1994
Publication title -
neurourology and urodynamics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.918
H-Index - 90
eISSN - 1520-6777
pISSN - 0733-2467
DOI - 10.1002/nau.1930130207
Subject(s) - medicine , animal study , animal model , urinary system , urodynamic testing , diuresis , urology , urinary bladder , abdominal cavity , surgery , anatomy , kidney
An animal model using minipigs to study urodynamic pressure flow relationships in the conscious animal is described. Port‐catheters were implanted subcutaneously in the hacks of 22 minipigs with access to the bladder (to measure intravesical pressure P ves ) and to the peritoneal cavity (to measure abdominal pressure P abd ). The subtracted pressure (P det = P ves = P abd ) was recorded during the storage phase following Furosemidc diuresis. Simultaneously, measurement of urinary flow (Q) during voiding was also recorded. Urodynamic studies were performed satisfactorily in all animals, and normal urodynamic profiles in minipigs were established. The minipig model allows reliable and reproducible measurement of pressure‐flow parameters in a conscious state and in the natural posture. © 1994 Wiley‐Liss, Inc.