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Effects of apomorphine and L‐dopa on the parkinsonian bladder
Author(s) -
Aranda Bernard,
Cramer Philippe
Publication year - 1993
Publication title -
neurourology and urodynamics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.918
H-Index - 90
eISSN - 1520-6777
pISSN - 0733-2467
DOI - 10.1002/nau.1930120302
Subject(s) - medicine , hyporeflexia , cystometry , apomorphine , hyperreflexia , dopaminergic , parkinson's disease , dopamine , urinary bladder , pallidotomy , anesthesia , urology , disease , surgery , deep brain stimulation , weakness
Neurogenic bladder frequently occurs in Parkinson's disease. Detrusor hyperreflexia is a consequence of nigrostriatal dopamine depletion, whereas the cause of hyporeflexia remains unclear. We compared the results of cystometry and urethral profilometry with and without apomorphine (and L dopa) in 12 idiopathic parkinsonians with urinary disorders free of dopaminergic treatment. Whereas hyperreflexic patients improved with apomorphine, and to a lesser extent with L dopa, these drugs had no effect on hyporeflexic patients. These results confirm the role of dopaminergic lesions in the occurrence of bladder hyperreflexia and the possible implication of nondopaminergic lesions in the occurrence of hyporeflexia.